Nicorandil

Nicorandil

Product Name : Nicorandil

Grade : IP / BP / USP

Therapeutic Category : Antianginals

CAS No : 65141-46-0

COA : Available

MSDS : Available

Description

Nicorandil is a vasodilatory drug used to treat angina.

Nicorandil stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).cGMP activates protein kinase G (PKG) which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the smooth muscle.

  • Description:- white crystalline powder,odorless(Results:Conforms)
  • Solubility:- Easily soluble in water, unsoluble in ethanol(Results:Conforms)
  • pH:- 6.0~7.5(Results:6.9)
  • Solution clarity and color:-solution should be clear and colorless(Results:Conforms)
  • Related substances:- 5’CMP 0.3% 0.01%
    Simple impurity 0.03%
    Total other impurity 0.10%
  • Chloride :- 0.05%(Results:Conforms)
  • Ammonium:- 0.05%(Results:Conforms)
  • Fe :-0.01%(Results:Conforms)
  • Phosphate:- 0.01%(Results:Conforms)
  • Loss on drying:- ≤6.0%(Results:1.3%)
  • Heavy metals:- 0.002%(Results:Conforms)
  • Arsenide:-0.0001%(Results:Conforms)
  • Bacterial Endotoxins:- 0.3EU/mg(Results:Conforms)
  • Microbial Limit:- Conforms(Results:Conforms)
  • Assay(on dried basis):-≥98.0%(Results:98.8%)
  • Conclusion:-The results conform with BP 2010

Packaging details:

Packaging details: 25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.

Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat.

Shelf Life: 5 years if sealed and store away from direct sun light.

Additional Information

The most widely recognized markets for this item incorporate the accompanying nations. If you don’t mind ask with us if your nation or district isn’t recorded:

ASIA: Saudi Arabia, Singapore, Syria, Philippines, Turkey, Turkmenistan, Afghanistan, Israel, Jordan, Pakistan, Russia, Uzbekistan, Yemen, Vietnam, Indonesia, Malaysia, Iran, Tajikistan, and so forth..

AFRICA: South Africa, Uganda, Ethiopia, Libya, Sudan, Congo, Gambia, Ivory Coast, Nigeria, Ghana, Kenya, Mauritius, Botswana, Egypt, and so forth.

NORTH & SOUTH AMERICA: Dominican Republic, Argentina, Guatemala, Guyana, Peru, Bolivia, Venezuela, USA, Canada, Panama, Trinidad and Tobago, Costa Rica, Puerto Rico, Brazil, Bahamas, Ecuador, and so forth .

EUROPE: France, Georgia, Germany, Hungary, Ireland, Iceland, Netherlands, Norway, Austria, Azerbaijan, Belarus, Belgium, Cyprus, Czech Republic, Denmark, Poland, Spain, Sweden, Switzerland, Ukraine, United Kingdom (UK) , Latvia, and so forth.

OCEANIA: Fiji, Australia, New Zealand, and so forth.